Intrinsic CD4(+) T cell sensitivity and response to pathogen are set and sustained by avidity for thymic and peripheral self-pMHC

T cell receptor (TCR) interactions with self-peptide-major histocompatibility complex (pMHC) are crucial to T cell development, but their role in peripheral T cell responses remains unclear. Specific and nonspecific stimulation of Listeria-specific LLO56 and LLO118 TCR transgenic T cells elicited di...

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Detalles Bibliográficos
Autores principales: Persaud, Stephen P., Parker, Chelsea R., Lo, Wan-Lin, Weber, K. Scott, Allen, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944141/
https://www.ncbi.nlm.nih.gov/pubmed/24487322
http://dx.doi.org/10.1038/ni.2822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944141/
https://www.ncbi.nlm.nih.gov/pubmed/24487322
http://dx.doi.org/10.1038/ni.2822

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