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Intrinsic CD4(+) T cell sensitivity and response to pathogen are set and sustained by avidity for thymic and peripheral self-pMHC
T cell receptor (TCR) interactions with self-peptide-major histocompatibility complex (pMHC) are crucial to T cell development, but their role in peripheral T cell responses remains unclear. Specific and nonspecific stimulation of Listeria-specific LLO56 and LLO118 TCR transgenic T cells elicited di...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944141/ https://www.ncbi.nlm.nih.gov/pubmed/24487322 http://dx.doi.org/10.1038/ni.2822 |