Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed

Misincorporation of genomic uracil and formation of DNA double strand breaks (DSBs) are known consequences of exposure to TS inhibitors such as pemetrexed. Uracil DNA glycosylase (UNG) catalyzes the excision of uracil from DNA and initiates DNA base excision repair (BER). To better define the relati...

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Detalles Bibliográficos
Autores principales: Weeks, L D, Zentner, G E, Scacheri, P C, Gerson, S L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944228/
https://www.ncbi.nlm.nih.gov/pubmed/24503537
http://dx.doi.org/10.1038/cddis.2013.477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944228/
https://www.ncbi.nlm.nih.gov/pubmed/24503537
http://dx.doi.org/10.1038/cddis.2013.477

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