The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells

Inhibitor-of-apoptosis protein (IAP) inhibitors have been reported to synergistically reduce cell viability in combination with a variety of chemotherapeutic drugs via targeted cellular IAP (cIAP) depletion. Here, we found that cIAP silencing sensitised colorectal cancer (CRC) cells to selenite-indu...

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Detalles Bibliográficos
Autores principales: Wu, P, Shi, K J, An, J J, Ci, Y L, Li, F, Hui, K Y, Yang, Y, Xu, C M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944232/
https://www.ncbi.nlm.nih.gov/pubmed/24577083
http://dx.doi.org/10.1038/cddis.2014.13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944232/
https://www.ncbi.nlm.nih.gov/pubmed/24577083
http://dx.doi.org/10.1038/cddis.2014.13

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