Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L)

Thioridazine has been known as an antipsychotic agent, but it also has anticancer activity. However, the effect of thioridazine on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitization has not yet been studied. Here, we investigated the ability of thioridazine to sensitize TR...

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Detalles Bibliográficos
Autores principales: Min, K-j, Seo, B R, Bae, Y C, Yoo, Y H, Kwon, T K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944252/
https://www.ncbi.nlm.nih.gov/pubmed/24556678
http://dx.doi.org/10.1038/cddis.2014.35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944252/
https://www.ncbi.nlm.nih.gov/pubmed/24556678
http://dx.doi.org/10.1038/cddis.2014.35

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