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Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest
Antifolates have a crucial role in the treatment of various cancers by inhibiting key enzymes in purine and thymidylate biosynthesis. However, the frequent emergence of inherent and acquired antifolate resistance in solid tumors calls for the development of novel therapeutic strategies to overcome t...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944254/ https://www.ncbi.nlm.nih.gov/pubmed/24556682 http://dx.doi.org/10.1038/cddis.2014.39 |