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Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest

Antifolates have a crucial role in the treatment of various cancers by inhibiting key enzymes in purine and thymidylate biosynthesis. However, the frequent emergence of inherent and acquired antifolate resistance in solid tumors calls for the development of novel therapeutic strategies to overcome t...

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Detalles Bibliográficos
Autores principales:	Raz, S, Sheban, D, Gonen, N, Stark, M, Berman, B, Assaraf, Y G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944254/ https://www.ncbi.nlm.nih.gov/pubmed/24556682 http://dx.doi.org/10.1038/cddis.2014.39

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