A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

Neuroblastoma (NB) is the most common extracranial neoplasm in children. In NB, loss of p53 function is largely due to cytoplasmic sequestration rather than mutation. Ubiquitin-conjugating enzyme E2 N (UBE2N), also known as Ubc13, is an E2 ubiquitin-conjugating enzyme that promotes formation of mono...

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Detalles Bibliográficos
Autores principales: Cheng, J, Fan, Y-H, Xu, X, Zhang, H, Dou, J, Tang, Y, Zhong, X, Rojas, Y, Yu, Y, Zhao, Y, Vasudevan, S A, Nuchtern, J G, Kim, E S, Chen, X, Lu, F, Yang, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944268/
https://www.ncbi.nlm.nih.gov/pubmed/24556694
http://dx.doi.org/10.1038/cddis.2014.54

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944268/
https://www.ncbi.nlm.nih.gov/pubmed/24556694
http://dx.doi.org/10.1038/cddis.2014.54

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