IgA EGFR antibodies mediate tumour killing in vivo

Currently all approved anti-cancer therapeutic monoclonal antibodies (mAbs) are of the IgG isotype, which rely on Fcgamma receptors (FcγRs) to recruit cellular effector functions. In vitro studies showed that targeting of FcαRI (CD89) by bispecific antibodies (bsAbs) or recombinant IgA resulted in m...

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Detalles Bibliográficos
Autores principales: Boross, Peter, Lohse, Stefan, Nederend, Maaike, Jansen, Johannes Hendrik Marco, van Tetering, Geert, Dechant, Michael, Peipp, Matthias, Royle, Louise, Liew, Li Phing, Boon, Louis, van Rooijen, Nico, Bleeker, Wim K, Parren, Paul W H I, van de Winkel, Jan G J, Valerius, Thomas, Leusen, Jeanette H W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944462/
https://www.ncbi.nlm.nih.gov/pubmed/23918228
http://dx.doi.org/10.1002/emmm.201201929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944462/
https://www.ncbi.nlm.nih.gov/pubmed/23918228
http://dx.doi.org/10.1002/emmm.201201929

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