Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance

Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β-amyloid (plaques) and hyper-phosphorylated Tau (tangles). Here we show that AD animals have high levels of insoluble parkin and decreased parkin-Beclin...

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Detalles Bibliográficos
Autores principales: Lonskaya, Irina, Hebron, Michaeline L, Desforges, Nicole M, Franjie, Alexander, Moussa, Charbel E-H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944464/
https://www.ncbi.nlm.nih.gov/pubmed/23737459
http://dx.doi.org/10.1002/emmm.201302771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944464/
https://www.ncbi.nlm.nih.gov/pubmed/23737459
http://dx.doi.org/10.1002/emmm.201302771

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