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Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance

Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β-amyloid (plaques) and hyper-phosphorylated Tau (tangles). Here we show that AD animals have high levels of insoluble parkin and decreased parkin-Beclin...

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Detalles Bibliográficos
Autores principales:	Lonskaya, Irina, Hebron, Michaeline L, Desforges, Nicole M, Franjie, Alexander, Moussa, Charbel E-H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Science Inc 2013
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944464/ https://www.ncbi.nlm.nih.gov/pubmed/23737459 http://dx.doi.org/10.1002/emmm.201302771

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