Another Facet to the Anticancer Response to Lamellarin D: Induction of Cellular Senescence through Inhibition of Topoisomerase I and Intracellular Ros Production

Lamellarin D (LamD) is a marine alkaloid with broad spectrum antitumor activities. Multiple intracellular targets of LamD, which affect cancer cell growth and induce apoptosis, have been identified. These include nuclear topoisomerase I, relevant kinases (such as cyclin-dependent kinase 2) and the m...

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Detalles Bibliográficos
Autores principales: Ballot, Caroline, Martoriati, Alain, Jendoubi, Manel, Buche, Sébastien, Formstecher, Pierre, Mortier, Laurent, Kluza, Jérome, Marchetti, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944515/
https://www.ncbi.nlm.nih.gov/pubmed/24473175
http://dx.doi.org/10.3390/md12020779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944515/
https://www.ncbi.nlm.nih.gov/pubmed/24473175
http://dx.doi.org/10.3390/md12020779

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