Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates

AIM: The preparation of novel PEGylated PAMAM (poly-amidoamine) dendrimers for delivery of anti-HIV drug Efavirenz is reported. METHOD AND MATERIALS: About 5.0 G PAMAM dendrimers are prepared by ethylene diamine core via Michael addition by divergent method. PEGylation is done by polyethylene glycol...

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Autores principales: Pyreddy, Suneela, Kumar, Pandurangan Dinesh, Kumar, Palanirajan Vijayaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944612/
https://www.ncbi.nlm.nih.gov/pubmed/24678457
http://dx.doi.org/10.4103/2230-973X.127735
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author Pyreddy, Suneela
Kumar, Pandurangan Dinesh
Kumar, Palanirajan Vijayaraj
author_facet Pyreddy, Suneela
Kumar, Pandurangan Dinesh
Kumar, Palanirajan Vijayaraj
author_sort Pyreddy, Suneela
collection PubMed
description AIM: The preparation of novel PEGylated PAMAM (poly-amidoamine) dendrimers for delivery of anti-HIV drug Efavirenz is reported. METHOD AND MATERIALS: About 5.0 G PAMAM dendrimers are prepared by ethylene diamine core via Michael addition by divergent method. PEGylation is done by polyethylene glycol 600 using epichlorhydrin as linker. PEGylated 5.0 G PAMAM dendrimers loaded with Efavirenz (EFV) are evaluated for FTIR, DSC, SEM, drug release, and stability studies. RESULTS AND CONCLUSION: From the results it is proved that this method is less time consuming, inexpensive, and reproducible. Drug-release studies indicate, PEGylated 5.0 G PAMAM-EFV dendrimers have shown prolonged drug-release property.
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spelling pubmed-39446122014-03-27 Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates Pyreddy, Suneela Kumar, Pandurangan Dinesh Kumar, Palanirajan Vijayaraj Int J Pharm Investig Original Research Article AIM: The preparation of novel PEGylated PAMAM (poly-amidoamine) dendrimers for delivery of anti-HIV drug Efavirenz is reported. METHOD AND MATERIALS: About 5.0 G PAMAM dendrimers are prepared by ethylene diamine core via Michael addition by divergent method. PEGylation is done by polyethylene glycol 600 using epichlorhydrin as linker. PEGylated 5.0 G PAMAM dendrimers loaded with Efavirenz (EFV) are evaluated for FTIR, DSC, SEM, drug release, and stability studies. RESULTS AND CONCLUSION: From the results it is proved that this method is less time consuming, inexpensive, and reproducible. Drug-release studies indicate, PEGylated 5.0 G PAMAM-EFV dendrimers have shown prolonged drug-release property. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3944612/ /pubmed/24678457 http://dx.doi.org/10.4103/2230-973X.127735 Text en Copyright: © International Journal of Pharmaceutical Investigation http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Pyreddy, Suneela
Kumar, Pandurangan Dinesh
Kumar, Palanirajan Vijayaraj
Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates
title Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates
title_full Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates
title_fullStr Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates
title_full_unstemmed Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates
title_short Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates
title_sort polyethylene glycolated pamam dendrimers-efavirenz conjugates
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944612/
https://www.ncbi.nlm.nih.gov/pubmed/24678457
http://dx.doi.org/10.4103/2230-973X.127735
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AT kumarpalanirajanvijayaraj polyethyleneglycolatedpamamdendrimersefavirenzconjugates

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