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Polygenic determinants of white matter volume derived from GWAS lack reproducibility in a replicate sample

A recent publication reported an exciting polygenic effect of schizophrenia (SCZ) risk variants, identified by a large genome-wide association study (GWAS), on total brain and white matter volumes in schizophrenic patients and, even more prominently, in healthy subjects. The aim of the present work...

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Detalles Bibliográficos
Autores principales: Papiol, S, Mitjans, M, Assogna, F, Piras, F, Hammer, C, Caltagirone, C, Arias, B, Ehrenreich, H, Spalletta, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944630/
https://www.ncbi.nlm.nih.gov/pubmed/24548877
http://dx.doi.org/10.1038/tp.2013.126