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Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala

The continuum of physiological anxiety up to psychopathology is not merely dependent on genes, but is orchestrated by the interplay of genetic predisposition, gene x environment and epigenetic interactions. Accordingly, inborn anxiety is considered a polygenic, multifactorial trait, likely to be sha...

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Detalles Bibliográficos
Autores principales: Sotnikov, S V, Markt, P O, Malik, V, Chekmareva, N Y, Naik, R R, Sah, A, Singewald, N, Holsboer, F, Czibere, L, Landgraf, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944631/
https://www.ncbi.nlm.nih.gov/pubmed/24518397
http://dx.doi.org/10.1038/tp.2013.127