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Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala
The continuum of physiological anxiety up to psychopathology is not merely dependent on genes, but is orchestrated by the interplay of genetic predisposition, gene x environment and epigenetic interactions. Accordingly, inborn anxiety is considered a polygenic, multifactorial trait, likely to be sha...
Autores principales: | Sotnikov, S V, Markt, P O, Malik, V, Chekmareva, N Y, Naik, R R, Sah, A, Singewald, N, Holsboer, F, Czibere, L, Landgraf, R |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944631/ https://www.ncbi.nlm.nih.gov/pubmed/24518397 http://dx.doi.org/10.1038/tp.2013.127 |
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