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Structure of Aurora B–INCENP in complex with barasertib reveals a potential transinhibitory mechanism
The Aurora family is a well conserved and well characterized group of serine-threonine kinases involved in the normal progression of mitosis. The deregulation of Aurora kinases impairs spindle assembly, checkpoint function and cell division. To date, many small molecules that compete with ATP for bi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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International Union of Crystallography
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944688/ https://www.ncbi.nlm.nih.gov/pubmed/24598913 http://dx.doi.org/10.1107/S2053230X14002118 |