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Structure of Aurora B–INCENP in complex with barasertib reveals a potential transinhibitory mechanism

The Aurora family is a well conserved and well characterized group of serine-threonine kinases involved in the normal progression of mitosis. The deregulation of Aurora kinases impairs spindle assembly, checkpoint function and cell division. To date, many small molecules that compete with ATP for bi...

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Detalles Bibliográficos
Autores principales:	Sessa, Fabio, Villa, Fabrizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2014
Materias:	Structural Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944688/ https://www.ncbi.nlm.nih.gov/pubmed/24598913 http://dx.doi.org/10.1107/S2053230X14002118

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