FKBP12.6 Activates RyR1: Investigating the Amino Acid Residues Critical for Channel Modulation

We have previously shown that FKBP12 associates with RyR2 in cardiac muscle and that it modulates RyR2 function differently to FKBP12.6. We now investigate how these proteins affect the single-channel behavior of RyR1 derived from rabbit skeletal muscle. Our results show that FKBP12.6 activates and...

Descripción completa

Detalles Bibliográficos
Autores principales: Venturi, Elisa, Galfré, Elena, O’Brien, Fiona, Pitt, Samantha J., Bellamy, Stuart, Sessions, Richard B., Sitsapesan, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2014
Materias:
Channels and Transporters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945099/
https://www.ncbi.nlm.nih.gov/pubmed/24559985
http://dx.doi.org/10.1016/j.bpj.2013.12.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945099/
https://www.ncbi.nlm.nih.gov/pubmed/24559985
http://dx.doi.org/10.1016/j.bpj.2013.12.041

Ejemplares similares