Structural Insights into E. coli Porphobilinogen Deaminase during Synthesis and Exit of 1-Hydroxymethylbilane

Porphobilinogen deaminase (PBGD) catalyzes the formation of 1-hydroxymethylbilane (HMB), a crucial intermediate in tetrapyrrole biosynthesis, through a step-wise polymerization of four molecules of porphobilinogen (PBG), using a unique dipyrromethane (DPM) cofactor. Structural and biochemical studie...

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Detalles Bibliográficos
Autores principales: Bung, Navneet, Pradhan, Meenakshi, Srinivasan, Harini, Bulusu, Gopalakrishnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945110/
https://www.ncbi.nlm.nih.gov/pubmed/24603363
http://dx.doi.org/10.1371/journal.pcbi.1003484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945110/
https://www.ncbi.nlm.nih.gov/pubmed/24603363
http://dx.doi.org/10.1371/journal.pcbi.1003484

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