Noise Genetics: Inferring Protein Function by Correlating Phenotype with Protein Levels and Localization in Individual Human Cells

To understand gene function, genetic analysis uses large perturbations such as gene deletion, knockdown or over-expression. Large perturbations have drawbacks: they move the cell far from its normal working point, and can thus be masked by off-target effects or compensation by other genes. Here, we...

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Detalles Bibliográficos
Autores principales: Farkash-Amar, Shlomit, Zimmer, Anat, Eden, Eran, Cohen, Ariel, Geva-Zatorsky, Naama, Cohen, Lydia, Milo, Ron, Sigal, Alex, Danon, Tamar, Alon, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945223/
https://www.ncbi.nlm.nih.gov/pubmed/24603725
http://dx.doi.org/10.1371/journal.pgen.1004176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945223/
https://www.ncbi.nlm.nih.gov/pubmed/24603725
http://dx.doi.org/10.1371/journal.pgen.1004176

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