Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling

Histone ubiquitinations are critical for the activation of the DNA damage response (DDR). In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively. However, it remains to be defined how the ubiquitin pathway engages chromatin to...

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Detalles Bibliográficos
Autores principales: Leung, Justin W., Agarwal, Poonam, Canny, Marella D., Gong, Fade, Robison, Aaron D., Finkelstein, Ilya J., Durocher, Daniel, Miller, Kyle M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945288/
https://www.ncbi.nlm.nih.gov/pubmed/24603765
http://dx.doi.org/10.1371/journal.pgen.1004178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945288/
https://www.ncbi.nlm.nih.gov/pubmed/24603765
http://dx.doi.org/10.1371/journal.pgen.1004178

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