Par6 is an essential mediator of apoptotic response to transforming growth factor beta in NMuMG immortalized mammary cells

BACKGROUND: We previously observed that the TGFbeta-Par6 pathway mediates loss of polarity and apoptosis in NMuMG cells. Here we investigate the contribution of Par6 versus TGFbeta receptor I activation to TGFbeta-induced apoptosis in association with changes in apico-basal polarity. We focus on the...

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Detalles Bibliográficos
Autores principales: Avery-Cooper, Geordon, Doerr, Meghan, Gilbert, Richard WD, Youssef, Mahmoud, Richard, Amy, Huether, Patricia, Viloria-Petit, Alicia M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945291/
https://www.ncbi.nlm.nih.gov/pubmed/24581220
http://dx.doi.org/10.1186/1475-2867-14-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945291/
https://www.ncbi.nlm.nih.gov/pubmed/24581220
http://dx.doi.org/10.1186/1475-2867-14-19

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