Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase

The amyloid precursor protein (APP) is a widely expressed type I transmembrane (TM) glycoprotein present at the neuronal synapse. The proteolytic cleavage by γ-secretase of its C-terminal fragment produces amyloid-β (Aβ) peptides of different lengths, the deposition of which is an early indicator of...

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Detalles Bibliográficos
Autores principales: Lemmin, Thomas, Dimitrov, Mitko, Fraering, Patrick C., Dal Peraro, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945338/
https://www.ncbi.nlm.nih.gov/pubmed/24469457
http://dx.doi.org/10.1074/jbc.M113.470781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945338/
https://www.ncbi.nlm.nih.gov/pubmed/24469457
http://dx.doi.org/10.1074/jbc.M113.470781

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