Pharmacological evidence of bradykinin regeneration from extended sequences that behave as peptidase–activated B(2) receptor agonists

While bradykinin (BK) is known to be degraded by angiotensin converting enzyme (ACE), we have recently discovered that Met-Lys-BK-Ser-Ser is paradoxically activated by ACE. We designed and evaluated additional “prodrug” peptides extended around the BK sequence as potential ligands that could be loca...

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Detalles Bibliográficos
Autores principales: Charest-Morin, Xavier, Roy, Caroline, Fortin, Émile-Jacques, Bouthillier, Johanne, Marceau, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945637/
https://www.ncbi.nlm.nih.gov/pubmed/24639651
http://dx.doi.org/10.3389/fphar.2014.00032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945637/
https://www.ncbi.nlm.nih.gov/pubmed/24639651
http://dx.doi.org/10.3389/fphar.2014.00032

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