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Pharmacological evidence of bradykinin regeneration from extended sequences that behave as peptidase–activated B(2) receptor agonists
While bradykinin (BK) is known to be degraded by angiotensin converting enzyme (ACE), we have recently discovered that Met-Lys-BK-Ser-Ser is paradoxically activated by ACE. We designed and evaluated additional “prodrug” peptides extended around the BK sequence as potential ligands that could be loca...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945637/ https://www.ncbi.nlm.nih.gov/pubmed/24639651 http://dx.doi.org/10.3389/fphar.2014.00032 |