A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome

Rett syndrome (RTT) is a neurodevelopmental disorder caused by loss-of-function mutations in the transcriptional modulator methyl-CpG-binding protein 2 (MECP2). One of the most prominent gene targets of MeCP2 is brain-derived neurotrophic factor (Bdnf), a potent modulator of activity-dependent synap...

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Detalles Bibliográficos
Autores principales: Xu, Xin, Kozikowski, Alan P., Pozzo-Miller, Lucas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945638/
https://www.ncbi.nlm.nih.gov/pubmed/24639629
http://dx.doi.org/10.3389/fncel.2014.00068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945638/
https://www.ncbi.nlm.nih.gov/pubmed/24639629
http://dx.doi.org/10.3389/fncel.2014.00068

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