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Structural Basis of Lipid-Driven Conformational Transitions in the KvAP Voltage Sensing Domain

Voltage-gated ion channels respond to transmembrane electric fields through reorientations of the positively charged S4 helix within the voltage-sensing domain (VSD). Despite a wealth of structural and functional data, the details of this conformational change remain controversial. Recent electrophy...

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Detalles Bibliográficos
Autores principales: Li, Qufei, Wanderling, Sherry, Somponspisut, Pornthep, Perozo, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946318/
https://www.ncbi.nlm.nih.gov/pubmed/24413055
http://dx.doi.org/10.1038/nsmb.2747