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Modulation of T(reg) function improves adenovirus vector-mediated gene expression in the airway

Virus vector -mediated gene transfer has been developed as a treatment for cystic fibrosis (CF) airway disease, a lethal inherited disorder caused by somatic mutations in the CFTR gene. The pathological pro-inflammatory environment of CF as well as the naïve and adaptive immunity induced by the viru...

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Detalles Bibliográficos
Autores principales: Nagai, Yasuhiro, Limberis, Maria P., Zhang, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946346/
https://www.ncbi.nlm.nih.gov/pubmed/24385144
http://dx.doi.org/10.1038/gt.2013.78