Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate

The unique methylerythritol phosphate (MEP) pathway for isoprenoid biosynthesis is essential in most bacterial pathogens. The first enzyme in this pathway, 1-deoxy-D-xylulose 5-phosphate (DXP) synthase, catalyzes a distinct thiamin diphosphate (ThDP)-dependent reaction to form DXP from D-glyceraldeh...

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Detalles Bibliográficos
Autores principales: Smith, Jessica M., Warrington, Nicole V., Vierling, Ryan J., Kuhn, Misty L., Anderson, Wayne F., Koppisch, Andrew T., Freel Meyers, Caren L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946878/
https://www.ncbi.nlm.nih.gov/pubmed/24169798
http://dx.doi.org/10.1038/ja.2013.105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946878/
https://www.ncbi.nlm.nih.gov/pubmed/24169798
http://dx.doi.org/10.1038/ja.2013.105

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