Inhibition of Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full T cell receptor signaling

T cell receptor (TCR) signaling is initiated by Src-family kinases (SFKs). To understand how C-terminal Src kinase (Csk), the negative regulator of SFKs, controls the basal state and the initiation of TCR signaling, we generated mice expressing a PP1-analog inhibitor-sensitive Csk variant (Csk(AS))....

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Detalles Bibliográficos
Autores principales: Xim Tan, Ying, Manz, Boryana N., Freedman, Tanya, Zhang, Chao, Shokat, Kevan M., Weiss, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946925/
https://www.ncbi.nlm.nih.gov/pubmed/24317039
http://dx.doi.org/10.1038/ni.2772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946925/
https://www.ncbi.nlm.nih.gov/pubmed/24317039
http://dx.doi.org/10.1038/ni.2772

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