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Inhibition of Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full T cell receptor signaling

T cell receptor (TCR) signaling is initiated by Src-family kinases (SFKs). To understand how C-terminal Src kinase (Csk), the negative regulator of SFKs, controls the basal state and the initiation of TCR signaling, we generated mice expressing a PP1-analog inhibitor-sensitive Csk variant (Csk(AS))....

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Detalles Bibliográficos
Autores principales:	Xim Tan, Ying, Manz, Boryana N., Freedman, Tanya, Zhang, Chao, Shokat, Kevan M., Weiss, Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946925/ https://www.ncbi.nlm.nih.gov/pubmed/24317039 http://dx.doi.org/10.1038/ni.2772

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