let-7-repressesed Shc translation delays replicative senescence

The p66Shc adaptor protein is an important regulator of lifespan in mammals, but the mechanisms responsible are still unclear. Here, we show that expression of p66Shc, p52Shc, and p46Shc is regulated at the post-transcriptional level by the microRNA let-7a. The levels of let-7a correlated inversely...

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Detalles Bibliográficos
Autores principales: Xu, Fang, Pang, Lijun, Cai, Xiaoyu, Liu, Xinwen, Yuan, Shuai, Fan, Xiuqin, Jiang, Bin, Zhang, Xiaowei, Dou, Yali, Gorospe, Myriam, Wang, Wengong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947057/
https://www.ncbi.nlm.nih.gov/pubmed/24165399
http://dx.doi.org/10.1111/acel.12176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947057/
https://www.ncbi.nlm.nih.gov/pubmed/24165399
http://dx.doi.org/10.1111/acel.12176

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