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Resistance to RAF inhibitors revisited

In early 2011, we reviewed the initial success of the RAF inhibitor, vemurafenib, in mutant V600 BRAF melanoma patients. It was soon evident that the response to RAF inhibitor is heterogeneous and that the short-term benefits are burdened by the development of resistance. The field has progressed ra...

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Detalles Bibliográficos
Autores principales: Hartsough, Edward, Shao, Yongping, Aplin, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947111/
https://www.ncbi.nlm.nih.gov/pubmed/24108405
http://dx.doi.org/10.1038/jid.2013.358