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Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic (13)C magnetic resonance spectroscopy
Despite the central role of the liver in the regulation of glucose and lipid metabolism there are currently no methods to directly assess hepatic oxidative metabolism in humans in vivo. By utilizing a novel (13)C-labeling strategy in combination with (13)C magnetic resonance spectroscopy we show tha...
Autores principales: | Befroy, Douglas E., Perry, Rachel J., Jain, Nimit, Dufour, Sylvie, Cline, Gary W., Trimmer, Jeff, Brosnan, Julia, Rothman, Douglas L., Petersen, Kitt Falk, Shulman, Gerald I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947269/ https://www.ncbi.nlm.nih.gov/pubmed/24317120 http://dx.doi.org/10.1038/nm.3415 |
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