Cargando…

Sterilization of granulomas is common in both active and latent tuberculosis despite extensive within-host variability in bacterial killing

Over 30% of the world’s population is infected with Mycobacterium tuberculosis (Mtb), yet only ~5–10% will develop clinical disease(1). Despite considerable effort, we understand little about what distinguishes individuals who progress to active tuberculosis (TB) from those who remain latent for dec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Philana Ling, Ford, Christopher B., Coleman, M. Teresa, Myers, Amy J., Gawande, Richa, Ioerger, Thomas, Sacchettini, James, Fortune, Sarah M., Flynn, JoAnne L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947310/ https://www.ncbi.nlm.nih.gov/pubmed/24336248 http://dx.doi.org/10.1038/nm.3412

Ejemplares similares

Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
por: Ford, Christopher B., et al.
Publicado: (2011)

Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization
por: Gideon, Hannah Priyadarshini, et al.
Publicado: (2015)

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis
por: Diedrich, Collin R., et al.
Publicado: (2020)

Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas
por: Cicchese, Joseph M., et al.
Publicado: (2020)

The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection
por: Ragheb, Mark N, et al.
Publicado: (2013)

Mycobacterium tuberculosis-Specific CD4 T Cells Expressing Transcription Factors T-Bet or RORγT Associate with Bacterial Control in Granulomas
por: Grant, Nicole L., et al.
Publicado: (2023)

PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis
por: Lin, Philana Ling, et al.
Publicado: (2016)

In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication
por: Marsden, Matthew D., et al.
Publicado: (2017)

T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques
por: Grant, Nicole L., et al.
Publicado: (2022)

Cancer kill code extension
por: Peter, Marcus E.
Publicado: (2023)

Reactivation of Latent Tuberculosis in Cynomolgus Macaques Infected with SIV Is Associated with Early Peripheral T Cell Depletion and Not Virus Load
por: Diedrich, Collin R., et al.
Publicado: (2010)

Sterilizing immunity: New opportunities for rational TB vaccine design
por: Sher, Alan, et al.
Publicado: (2021)

Genome Analysis of Multi- and Extensively-Drug-Resistant Tuberculosis from KwaZulu-Natal, South Africa
por: Ioerger, Thomas R., et al.
Publicado: (2009)

Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells
por: Ke, Ruian, et al.
Publicado: (2015)

A report of disseminated actinic granuloma: An unusually extensive presentation
por: Ahlers, Carolyn, et al.
Publicado: (2023)

MON-069 Uncontrolled Central Precocious Puberty Patient Against GnRH Agonist, After Showing Granuloma Formation and Sterile Abscess to Both Leuprorelin Acetate and Triptorelin Actate
por: Kim, Dae Hyun, et al.
Publicado: (2020)

THE REACTION OF THE LUNGS TO THE INTRABRONCHIAL INSUFFLATION OF KILLED VIRULENT PNEUMOCOCCI AND OF PLAIN STERILE BOUILLON
por: Wollstein, Martha, et al.
Publicado: (1913)

Monocytes Latently Infected with Human Cytomegalovirus Evade Neutrophil Killing
por: Elder, Elizabeth, et al.
Publicado: (2019)

Role of Dendritic Cells in Exposing Latent HIV-1 for the Kill
por: Kristoff, Jan, et al.
Publicado: (2019)

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
por: Watanabe, Yasunori, et al.
Publicado: (2020)

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
por: Gideon, Hannah P., et al.
Publicado: (2022)

Identification of S23 causing both interspecific hybrid male sterility and environment-conditioned male sterility in rice
por: Fang, Chaowei, et al.
Publicado: (2019)

Sterile necrotizing and non-necrotizing granulomas in a heart transplant patient with history of PTLD: A unique finding
por: Piening, Nicholas, et al.
Publicado: (2019)

Causes and Treatment of Sterility in Both Sexes, and Fecundation by Artificial Methods
Publicado: (1891)

Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection
por: Jalbert, Emilie, et al.
Publicado: (2023)

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities
por: Carey, Allison F., et al.
Publicado: (2018)

Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities
por: Carey, Allison F., et al.
Publicado: (2019)

Host transcription in active and latent tuberculosis
por: Fortune, Sarah M, et al.
Publicado: (2010)

Interleukin-36 is vasculoprotective in both sexes despite sex-specific changes in the coronary microcirculation response to IR injury
por: El-Awaisi, Juma, et al.
Publicado: (2023)

Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape
por: Shell, Scarlet S., et al.
Publicado: (2015)

Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis
por: Martin, Constance J., et al.
Publicado: (2017)

Mathematical Modeling of Tuberculosis Granuloma Activation
por: Ruggiero, Steve M., et al.
Publicado: (2017)

Perforating Granuloma Annulare Mimicking Psoriasis
por: Jacob, Joanne S, et al.
Publicado: (2020)

Characterization of Host and Microbial Determinants in Individuals with Latent Tuberculosis Infection Using a Human Granuloma Model
por: Guirado, Evelyn, et al.
Publicado: (2015)

Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura
por: Coleman, Christopher, et al.
Publicado: (2014)

Donovanosis (Granuloma Inguinale, Granuloma Venereum)
por: Weinman, David
Publicado: (1956)

Development of Disseminated Tuberculosis with Intestinal Involvement due to Adalimumab Administration Despite Latent Tuberculosis Treatment
por: Ikuta, Kozo, et al.
Publicado: (2019)

The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
por: McMyn, Natalie F., et al.
Publicado: (2023)

Implications of HIV-1 Nef for “Shock and Kill” Strategies to Eliminate Latent Viral Reservoirs
por: Kuang, Xiaomei T., et al.
Publicado: (2018)

Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies
por: De Groof, Timo W. M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gg7e031kmh7cgmv5tgmea8c35f