Improved Expression of Recombinant Human Factor IX by Co-expression of GGCX, VKOR and Furin

Recombinant human FIX concentrates (rhFIX) are essential in the treatment and prevention of bleeding in the bleeding disorder haemophilia B. However, due to the complex nature of FIX production yields are low which leads to high treatment costs. Here we report the production of rhFIX with substantia...

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Detalles Bibliográficos
Autores principales: Liu, Jianming, Jonebring, Anna, Hagström, Jonas, Nyström, Ann-Christin, Lövgren, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947961/
https://www.ncbi.nlm.nih.gov/pubmed/24567122
http://dx.doi.org/10.1007/s10930-014-9550-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947961/
https://www.ncbi.nlm.nih.gov/pubmed/24567122
http://dx.doi.org/10.1007/s10930-014-9550-5

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