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CaMKII-dependent regulation of cardiac Na(+) homeostasis

Na(+) homeostasis is a key regulator of cardiac excitation and contraction. The cardiac voltage-gated Na(+) channel, Na(V)1.5, critically controls cell excitability, and altered channel gating has been implicated in both inherited and acquired arrhythmias. Ca(2)(+)/calmodulin-dependent protein kinas...

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Detalles Bibliográficos
Autores principales: Grandi, Eleonora, Herren, Anthony W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948048/
https://www.ncbi.nlm.nih.gov/pubmed/24653702
http://dx.doi.org/10.3389/fphar.2014.00041