Mutational and Structural Analysis of KIR3DL1 Reveals a Lineage-Defining Allotypic Dimorphism That Impacts Both HLA and Peptide Sensitivity

Killer Ig-like receptors (KIRs) control the activation of human NK cells via interactions with peptide-laden HLAs. KIR3DL1 is a highly polymorphic inhibitory receptor that recognizes a diverse array of HLA molecules expressing the Bw4 epitope, a group with multiple polymorphisms incorporating varian...

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Detalles Bibliográficos
Autores principales: O’Connor, Geraldine M., Vivian, Julian P., Widjaja, Jacqueline M., Bridgeman, John S., Gostick, Emma, Lafont, Bernard A. P., Anderson, Stephen K., Price, David A., Brooks, Andrew G., Rossjohn, Jamie, McVicar, Daniel W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2014
Materias:
Molecular and Structural Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948114/
https://www.ncbi.nlm.nih.gov/pubmed/24563253
http://dx.doi.org/10.4049/jimmunol.1303142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948114/
https://www.ncbi.nlm.nih.gov/pubmed/24563253
http://dx.doi.org/10.4049/jimmunol.1303142

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