Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood leukemia

ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute lymphoblastic leukemia. It is responsible for the initiation of leukemia but also indispensable for disease maintenance and propagation, although its function in these latter processes is less clear. We therefore investigated the eff...

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Detalles Bibliográficos
Autores principales: Kaindl, U, Morak, M, Portsmouth, C, Mecklenbräuker, A, Kauer, M, Zeginigg, M, Attarbaschi, A, Haas, O A, Panzer-Grümayer, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948158/
https://www.ncbi.nlm.nih.gov/pubmed/24240203
http://dx.doi.org/10.1038/leu.2013.345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948158/
https://www.ncbi.nlm.nih.gov/pubmed/24240203
http://dx.doi.org/10.1038/leu.2013.345

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