Regulation of human telomerase splicing by RNA:RNA pairing

Telomerase adds telomeric repeats onto chromosome ends and is almost universally upregulated in human cancers. Here we demonstrate that RNA:RNA pairing regulates splicing of the catalytic subunit of human telomerase (TERT). Human alleles contain a variable number of 38 bp repeats within TERT intron...

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Detalles Bibliográficos
Autores principales: Wong, Mandy S., Shay, Jerry W., Wright, Woodring E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948165/
https://www.ncbi.nlm.nih.gov/pubmed/24577044
http://dx.doi.org/10.1038/ncomms4306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948165/
https://www.ncbi.nlm.nih.gov/pubmed/24577044
http://dx.doi.org/10.1038/ncomms4306

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