IGHV1-69 B Cell Chronic Lymphocytic Leukemia Antibodies Cross-React with HIV-1 and Hepatitis C Virus Antigens as Well as Intestinal Commensal Bacteria

B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutated immunoglobulin heavy variable regions (IGHVs) use the IGHV1-69 B cell receptor (BCR) in 25% of cases. Since HIV-1 envelope gp41 antibodies also frequently use IGHV1-69 gene segments, we hypothesized that IGHV1-69 B-CLL precurs...

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Detalles Bibliográficos
Autores principales: Hwang, Kwan-Ki, Trama, Ashley M., Kozink, Daniel M., Chen, Xi, Wiehe, Kevin, Cooper, Abby J., Xia, Shi-Mao, Wang, Minyue, Marshall, Dawn J., Whitesides, John, Alam, Munir, Tomaras, Georgia D., Allen, Steven L., Rai, Kanti R., McKeating, Jane, Catera, Rosa, Yan, Xiao-Jie, Chu, Charles C., Kelsoe, Garnett, Liao, Hua-Xin, Chiorazzi, Nicholas, Haynes, Barton F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948690/
https://www.ncbi.nlm.nih.gov/pubmed/24614505
http://dx.doi.org/10.1371/journal.pone.0090725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948690/
https://www.ncbi.nlm.nih.gov/pubmed/24614505
http://dx.doi.org/10.1371/journal.pone.0090725

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