Cargando…

IGHV1-69 B Cell Chronic Lymphocytic Leukemia Antibodies Cross-React with HIV-1 and Hepatitis C Virus Antigens as Well as Intestinal Commensal Bacteria

B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutated immunoglobulin heavy variable regions (IGHVs) use the IGHV1-69 B cell receptor (BCR) in 25% of cases. Since HIV-1 envelope gp41 antibodies also frequently use IGHV1-69 gene segments, we hypothesized that IGHV1-69 B-CLL precurs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hwang, Kwan-Ki, Trama, Ashley M., Kozink, Daniel M., Chen, Xi, Wiehe, Kevin, Cooper, Abby J., Xia, Shi-Mao, Wang, Minyue, Marshall, Dawn J., Whitesides, John, Alam, Munir, Tomaras, Georgia D., Allen, Steven L., Rai, Kanti R., McKeating, Jane, Catera, Rosa, Yan, Xiao-Jie, Chu, Charles C., Kelsoe, Garnett, Liao, Hua-Xin, Chiorazzi, Nicholas, Haynes, Barton F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948690/ https://www.ncbi.nlm.nih.gov/pubmed/24614505 http://dx.doi.org/10.1371/journal.pone.0090725

Ejemplares similares

IGHV1-69-Encoded Antibodies Expressed in Chronic Lymphocytic Leukemia React with Malondialdehyde–Acetaldehyde Adduct, an Immunodominant Oxidation-Specific Epitope
por: Que, Xuchu, et al.
Publicado: (2013)

IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity
por: Avnir, Yuval, et al.
Publicado: (2016)

Celebrating 20 Years of IGHV Mutation Analysis in CLL
por: Chiorazzi, Nicholas, et al.
Publicado: (2020)

Erratum: IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity
por: Avnir, Yuval, et al.
Publicado: (2016)

Stringent and complex sequence constraints of an IGHV1–69 broadly neutralizing antibody to influenza HA stem
por: Teo, Qi Wen, et al.
Publicado: (2023)

Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation
por: Kepler, Thomas B., et al.
Publicado: (2014)

HIV-1 Envelope gp41 Broadly Neutralizing Antibodies: Hurdles for Vaccine Development
por: Verkoczy, Laurent, et al.
Publicado: (2014)

Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies
por: Kelsoe, Garnett, et al.
Publicado: (2013)

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope
por: Avnir, Yuval, et al.
Publicado: (2017)

Prevalence of Allelic Variants and Clonality of IGHV1-69 Expressing B-Cells in Patients with Different Severity of COVID 19 Disease
por: Panovska-Stavridis, Irina, et al.
Publicado: (2021)

The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia
por: Yuan, Chaohui, et al.
Publicado: (2017)

AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes
por: Tang, Catherine, et al.
Publicado: (2020)

Unmutated IGHV1-69 CLL Clone Displays a Distinct Gene Expression Profile by a Comparative qRT-PCR Assay
por: Mimmi, Selena, et al.
Publicado: (2022)

Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants
por: Yan, Qihong, et al.
Publicado: (2022)

Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia
por: Kaufman, Matthew, et al.
Publicado: (2022)

Novel Method for High-Throughput Full-Length IGHV-D-J Sequencing of the Immune Repertoire from Bulk B-Cells with Single-Cell Resolution
por: Vergani, Stefano, et al.
Publicado: (2017)

Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course
por: Bagnara, Davide, et al.
Publicado: (2021)

Fc receptor-like 2 (FCRL2) is a novel marker of low-risk CLL and refines prognostication based on IGHV mutation status
por: Shea, Lauren K., et al.
Publicado: (2019)

IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load
por: Hussmann, Dianna, et al.
Publicado: (2021)

Functional, Non-Clonal IgM(a)-Restricted B Cell Receptor Interactions with the HIV-1 Envelope gp41 Membrane Proximal External Region
por: Verkoczy, Laurent, et al.
Publicado: (2009)

Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
por: Haynes, Barton F., et al.
Publicado: (2022)

Progress with induction of HIV broadly neutralizing antibodies in the Duke Consortia for HIV/AIDS Vaccine Development
por: Haynes, Barton F., et al.
Publicado: (2023)

React and React Native
por: Boduch, Adam
Publicado: (2017)

React and React Native
por: Boduch, Adam
Publicado: (2020)

Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV(mut) and IgHV(unmut) subgroups
por: Burns, A, et al.
Publicado: (2018)

Association of an IGHV3-66 gene variant with Kawasaki disease
por: Johnson, Todd A., et al.
Publicado: (2020)

Erratum: Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV(mut) and IgHV(unmut) subgroups
por: Burns, A, et al.
Publicado: (2017)

Correction: Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV(mut) and IgHV(unmut) subgroups
por: Burns, A, et al.
Publicado: (2019)

Isolation of HIV-1-Neutralizing Mucosal Monoclonal Antibodies from Human Colostrum
por: Friedman, James, et al.
Publicado: (2012)

SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens
por: Bartolo, Laurent, et al.
Publicado: (2021)

SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens
por: Bartolo, Laurent, et al.
Publicado: (2022)

H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded Anti-Hemagglutinin Antibodies Than Influenza Vaccination
por: Moody, M. Anthony, et al.
Publicado: (2011)

Advancing Toward HIV-1 Vaccine Efficacy through the Intersections of Immune Correlates
por: Tomaras, Georgia D., et al.
Publicado: (2013)

Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
por: Henderson, Rory, et al.
Publicado: (2019)

Lack of IgA envelope-reactive antibody producing cells in terminal ileum in early and chronic HIV-1 infection
por: Trama, AM, et al.
Publicado: (2012)

The Commensal Microbiota Drives Immune Homeostasis
por: Arrieta, Marie-Claire, et al.
Publicado: (2012)

Worldwide genetic variation of the IGHV and TRBV immune receptor gene families in humans
por: Luo, Shishi, et al.
Publicado: (2019)

脾边缘区淋巴瘤患者IGHV突变状态分析
Publicado: (2016)

PB1869: IGHV REPERTOIRE FEATURES IN KAZAKHSTAN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS
por: Klodzinskiy, A., et al.
Publicado: (2022)

Learning React: functional web development with React and Redux
por: Banks, Alex, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_h8279jjcqueclv4i7lr0glstk6