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Reactive Oxygen Species Production and Mitochondrial Dysfunction in White Blood Cells Are Not Valid Biomarkers of Ageing in the Very Old

Reliable and valid biomarkers of ageing (BoA) are needed to understand mechanisms, test interventions and predict the timing of adverse health events associated with ageing. Since increased reactive oxygen species (ROS) production and mitochondrial dysfunction are consequences of cellular senescence...

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Detalles Bibliográficos
Autores principales: Wiley, Laura, Ashok, Deepthi, Martin-Ruiz, Carmen, Talbot, Duncan C. S., Collerton, Joanna, Kingston, Andrew, Davies, Karen, Chinnery, Patrick F., Catt, Michael, Jagger, Carol, Kirkwood, Thomas B. L., von Zglinicki, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948743/
https://www.ncbi.nlm.nih.gov/pubmed/24614678
http://dx.doi.org/10.1371/journal.pone.0091005