Higher-Order Septin Assembly Is Driven by GTP-Promoted Conformational Changes: Evidence From Unbiased Mutational Analysis in Saccharomyces cerevisiae

Septin proteins bind GTP and heterooligomerize into filaments with conserved functions across a wide range of eukaryotes. Most septins hydrolyze GTP, altering the oligomerization interfaces; yet mutations designed to abolish nucleotide binding or hydrolysis by yeast septins perturb function only at...

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Detalles Bibliográficos
Autores principales: Weems, Andrew D., Johnson, Courtney R., Argueso, Juan Lucas, McMurray, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2014
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948802/
https://www.ncbi.nlm.nih.gov/pubmed/24398420
http://dx.doi.org/10.1534/genetics.114.161182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948802/
https://www.ncbi.nlm.nih.gov/pubmed/24398420
http://dx.doi.org/10.1534/genetics.114.161182

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