7,8-Dihydroxyflavone, a Small Molecule TrkB Agonist, Improves Spatial Memory and Increases Thin Spine Density in a Mouse Model of Alzheimer Disease-Like Neuronal Loss

Augmenting BDNF/TrkB signaling has been demonstrated to be a promising strategy for reversing cognitive deficits in preclinical models of Alzheimer disease (AD). Although these studies highlight the potential of targeting BDNF/TrkB signaling, this strategy has not yet been tested in a model that dev...

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Detalles Bibliográficos
Autores principales: Castello, Nicholas A., Nguyen, Michael H., Tran, Jenny D., Cheng, David, Green, Kim N., LaFerla, Frank M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948846/
https://www.ncbi.nlm.nih.gov/pubmed/24614170
http://dx.doi.org/10.1371/journal.pone.0091453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948846/
https://www.ncbi.nlm.nih.gov/pubmed/24614170
http://dx.doi.org/10.1371/journal.pone.0091453

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