Indoxyl Sulfate Downregulates Expression of Mas Receptor via OAT3/AhR/Stat3 Pathway in Proximal Tubular Cells

Renin-angiotensin system (RAS) plays a pivotal role in chronic kidney disease (CKD). Angiotensin converting enzyme-related carboxypeptidase 2 (ACE2)/angiotensin (Ang)-(1–7)/Mas receptor axis counteracts the deleterious actions of Ang II. ACE2 exerts its actions by cleaving Ang II into Ang-(1–7) whic...

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Detalles Bibliográficos
Autores principales: Ng, Hwee-Yeong, Yisireyili, Maimaiti, Saito, Shinichi, Lee, Chien-Te, Adelibieke, Yelixiati, Nishijima, Fuyuhiko, Niwa, Toshimitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948887/
https://www.ncbi.nlm.nih.gov/pubmed/24614509
http://dx.doi.org/10.1371/journal.pone.0091517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948887/
https://www.ncbi.nlm.nih.gov/pubmed/24614509
http://dx.doi.org/10.1371/journal.pone.0091517

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