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Chemical construction and structural permutation of neurotoxic natural product, antillatoxin: importance of the three-dimensional structure of the bulky side chain
Antillatoxin 1 is a unique natural product that displays potent neurotoxic and neuritogenic activities through activation of voltage-gated sodium channels. The peptidic macrocycle of 1 was attached to a side chain with an exceptionally high degree of methylation. In this review, we discuss the total...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Japan Academy
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948940/ https://www.ncbi.nlm.nih.gov/pubmed/24522155 http://dx.doi.org/10.2183/pjab.90.56 |