Ubiquitination Events That Regulate Recombination of Immunoglobulin Loci Gene Segments

Programed DNA mutagenesis events in the immunoglobulin (Ig) loci of developing B cells utilize the common and conserved mechanism of protein ubiquitination for subsequent proteasomal degradation to generate the required antigen-receptor diversity. Recombinase proteins RAG1 and RAG2, necessary for V(...

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Detalles Bibliográficos
Autores principales: Chao, Jaime, Rothschild, Gerson, Basu, Uttiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949197/
https://www.ncbi.nlm.nih.gov/pubmed/24653725
http://dx.doi.org/10.3389/fimmu.2014.00100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949197/
https://www.ncbi.nlm.nih.gov/pubmed/24653725
http://dx.doi.org/10.3389/fimmu.2014.00100

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