A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

Approximately 70% of KRAS-positive colorectal cancers (CRCs) have a CpG island methylator phenotype (CIMP) characterized by aberrant DNA hypermethylation and transcriptional silencing of many genes. The factors involved in, and the mechanistic basis of, CIMP is not understood. Among the CIMP genes a...

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Detalles Bibliográficos
Autores principales: Serra, Ryan W, Fang, Minggang, Park, Sung Mi, Hutchinson, Lloyd, Green, Michael R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949416/
https://www.ncbi.nlm.nih.gov/pubmed/24623306
http://dx.doi.org/10.7554/eLife.02313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949416/
https://www.ncbi.nlm.nih.gov/pubmed/24623306
http://dx.doi.org/10.7554/eLife.02313

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